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Concerned about his friend's cocaine use, Dr. Watson tricks Sherlock Holmes into travelling to Vienna, where Holmes enters the care of Sigmund Freud. Freud attempts to solve the mysteries of Holmes' subconscious, while Holmes devotes himself to solving a mystery involving the kidnapping of Lola Deveraux.
On his uncle's death Sir Henry Baskerville returns from Canada to take charge of his ancestral hall on the desolate moors of Devonshire, and finds that Sherlock Holmes is there to investigate the local belief that his uncle was killed by a monster hound that has roamed the moors since 1650, and is likely to strike again at Sir Henry.
Holmes and Watson board a passenger train bound from London to Edinburgh, to guard the Star of Rhodesia, an enormous diamond worth a fortune belonging to an elderly woman of wealth; but within the first hour of the trip, the woman's son is murdered and the diamond stolen and any of the passengers in their car could be the killer thief.
Sherlock Holmes is drawn into the case of Jack the Ripper who is killing prostitutes in London's East End. Assisted by Dr. Watson, and using information provided by a renowned psychic, Robert Lees, Holmes finds that the murders may have its roots in a Royal indiscretion and that a cover-up is being managed by politicians at the highest level, all of whom happen to be Masons.
Sherlock Holmes and Dr. Watson are called in to unravel a mysterious curse that has plagued the Baskerville family for generations. When Sir Charles Baskerville is found dead, his heir, Sir Henry, begs Holmes to save him from the terrifying supernatural hound that has brought fear and death to his household.
The Good Comrades are a collection of varied gentlemen who crave one thing - solitude. They reside at Drearcliff House, ancestral home of their eldest member. All seems serene and convivial until one by one the members begin to perish in the most grisly of manners. Foul play is suspected by the Good Comrades' insurance agent, who turns to Sherlock Holmes and Dr. John Watson for guidance.
Sherlock Holmes' problem with disturbing dreams proves to be both an impediment and an aid in the search for a missing woman.
For years, a blackmailer has been preying on the weaknesses of others throughout London. When Holmes hears of the utter misery this mystery man is creating, he adopts a campaign to thwart his evil scheming. The campaign astonishes Dr. Watson by its strangeness and finds Holmes falling in love.
When a woman is found dead with her throat torn out, the local villagers blame a supernatural monster. But Sherlock Holmes, who gets drawn into the case from nearby Quebec, suspects a human murderer.
Sir Arthur Conan Doyle's Sherlock Holmes - the world's greatest detective - faces a most alluring adversary... Legendary opera star Irene Adler is threatening to destroy the King of Bohemia's reputation with proof of their illicit affair. The evidence? A photograph. Her ransom? The king's hand in marriage. But not only does investigating detective Sherlock Holmes already know Irene from the past, he also knows that the queen of manipulation would never resort to such a common crime. After uncovering her true ambitions, Holmes draws the cunning songstress into a well-matched game of cat and mouse
When Watson reads from the newspaper there have been two similar murders near Whitechapel in a few days, Sherlock Holmes' sharp deductive is immediately stimulated to start its merciless method of elimination after observation of every apparently meaningless detail. He guesses right the victims must be street whores, and doesn't need long to work his way trough a pawn shop, an aristocratic family's stately home, a hospital and of course the potential suspects and (even unknowing) witnesses who are the cast of the gradually unraveled story of the murderer and his motive.
Sir Charles Baskerville dies on the moor under mysterious circumstances and rumors abound about a demonic hound. When the American heir arrives to take charge, a family friend calls in Holmes and Watson to get to the heart of the mystery.
A film projectionist longs to be a detective, and puts his meagre skills to work when he is framed by a rival for stealing his girlfriend's father's pocketwatch.
The famous Borgia Pearl, a valuable gem with a history of bringing murder and misfortune to its owner since the days of the Borgias, is brought to London, thanks in part to Sherlock Holmes. But before long the jewel is stolen, due to an error on Holmes' part, and shortly thereafter, a series of horrible murders begin, the murderer leaving his victims with their spines snapped and surrounded by a mass of smashed china.
Sherlock Holmes is as dashing as ever, but with a little secret: Dr. Watson is the brains behind the operation. When Reginald Kincaid, the actor he has hired to play Holmes becomes insufferable, Watson fires him and tries to go out on his own, but finds that he has done too good a job building Holmes up in the public's mind.
Sherlock Holmes investigates when young women around London turn up murdered, each with a finger severed. Scotland Yard suspects a madman, but Holmes believes the killings to be part of a diabolical plot.
Sherlock Holmes investigates strange and tragic happenings in a village that appear linked to a man who seems to be like a vampire.
Mary Morstan has received a pearl in the post every year since her father's disappearance. This leads Holmes and Watson to the truth about a secret pact between four convicts during the Indian Rebellion of 1857.
Early in his crime-solving career, Sherlock Holmes attempts to prevent Moriarty from cornering the heroin market.
After the death of his wife, wealthy retiree Justin Playfair creates a fantasy world for himself in which he is the legendary detective Sherlock Holmes, even dressing like the character. Out of concern for Justin's money more than his health, his brother Blevins puts him under the care of psychiatrist Dr. Mildred Watson. As Dr. Watson grows fond of Justin, she begins to play along with his theories, eventually becoming an assistant in his investigations.