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In Baker City, London, the city of fog, the famous trademark Detective Holmes has a pipe as its trademark. Together with his assistant Watson, he uses his clear mind to solve difficult cases.
Holmes is hired by the débutante Lady Eva Blackwell to retrieve compromising letters from a blackmailer:
Sherlock Holmes must track down his nemesis, Professor Moriarty, after the villain kidnaps Holmes' brother, Mycroft. The evil doctor is forcing his captive to decode highly classified military documents.
Holmes goes on the trail of a Rembrandt painting, stolen by a drug-addicted artist.
Two mediocre detectives try and catch a notorious pickpocket. Meanwhile, an innocent man is mistaken for the pickpocket and is forced to put on a disguise to evade capture.
Special reveals for the first time the astonishing impact that Holmes has had on the development of real criminal investigation and forensic techniques.